Sequence variation is particularly relevant to infectious pathogens that mutate in response to antimicrobial therapy. Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase ...
† Drugs combined with NRTIs or NRTIs/NNRTIs are not listed. NNRTIs: Non-nucleoside reverse-transcriptase inhibitors; NRTIs: Nucleos(t)ide analog reverse-transcriptase inhibitors. Drug-resistance amino ...
Amid the unprecedented challenges presented by the COVID-19 pandemic, a once obscure enzyme found itself in the spotlight: reverse transcriptase. As laboratories worldwide rushed to develop reliable ...
The Aicardi–Goutières syndrome is a genetic encephalopathy that is associated with childhood illness and death. The syndrome is hypothesized to be due to misidentification of self-derived nucleic ...
Genotypic surveys suggest that human immunodeficiency virus type 1 (HIV- 1) and HIV- 2 evolve different sets of mutations in response to nudeoside reverse- transcriptase inhibitors (NRTIs). We used ...
One of the hallmarks of many DNA polymerases is that they proofread as they copy DNA, ensuring high-fidelity duplicates of an organism’s genome. This error-checking ability is missing from enzymes ...
RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...
New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells. The transcriptase, Telomerase Reverse Transcriptase (TERT), is ...
Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The disease has proven difficult to develop new treatments for, and available ...
Partnership delivers advanced reverse transcriptase technology to enhance sensitivity, robustness and reproducibility of molecular analysis in clinical, applied and pharmaceutical applications Promega ...
The global reverse transcriptase enzymes industry has witnessed remarkable growth and is anticipated to further expand, reaching a valuation of US$ 335.0 Million in 2022 and projected to escalate to ...
† Drugs combined with NRTIs or NRTIs/NNRTIs are not listed. NNRTIs: Non-nucleoside reverse-transcriptase inhibitors; NRTIs: Nucleos(t)ide analog reverse-transcriptase inhibitors. Drug-resistance amino ...
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